Jeremy J. Barr

This study identifies a novel jumbo phage with a tripartite genome architecture and describes its terminal elements' role in infection.

This study determines the crystal structure of AbTir, revealing how its coiled-coil domain inhibits NAD+ nucleosidase activity by disrupting symmetry and preventing NAD+ binding site formation.

This study identifies and characterizes prophage induction mechanisms in gut bacteria, showing that DNA damage reliably triggers induction of prophages encoding CI-like repressors.

The paper identifies pre-existing anti-prophage antibodies and bacterial heteroresistance as factors contributing to phage therapy failure in a patient with chronic infection.

This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.

The paper develops a phage cocktail, Entelli-02, effective against multidrug-resistant Enterobacter cloacae complex strains with 99% coverage and 92% efficacy in a hospital strain collection.

This paper describes the construction and high-yield production of virus-like particles for delivering antimicrobial genes, demonstrating their effectiveness in bacterial cultures and human cell models.