A mutation in vesicular acetylcholine transporter increases tubulin acetylation compromising axonal transport
Cheng-Shan Kuo, Meng-Chieh Wang, Vignesh Mahendran Ruckmani, Muhammad Safwan Khawaja, Odvogmed Bayansan, Syed Nooruzuha Barmaver, Prerana Bhan, Oliver Ingvar Wagner
This study identifies a mutation in the vesicular acetylcholine transporter (UNC-17) that increases tubulin acetylation, impairing axonal transport by disrupting interactions between UNC-104, UNC-17, and MEC-17.
Journal of Neurochemistry · Dec 1, 2025Peer-reviewedCell Biology