LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3
Ningbo Zheng, Roshni Jaffery, Ashley M. Guerrero, Jiakai Hou, Yuchen Pan, Fang Zhou, Si Chen, Chenggui Xu, Nicholas A. Egan, Ritu Bohat, Ken Chen, Michael A. Schwarzschild, Xiqun Chen, Weiyi Peng
This study shows that the LRRK2 G2019S mutation impairs Th9 and Treg cell differentiation while enhancing Th2 differentiation through JAK/STAT3 signaling in T cells.
bioRxiv · Feb 28, 2024 · PreprintImmunology