Neoadjuvant anti-4-1BB confers protection against spontaneous metastasis through low-affinity intratumor CD8+ T cells in triple-negative breast cancer
Bryan Jian Wei Lim, Mingyong Liu, Liuyang Wang, Sharleen Li Ying Kong, Tao Yin, Chengsong Yan, Kun Xiang, Chengjie Cao, Haiyang Wu, Ariana Mihai, Felicia P. Tay, Ergang Wang, Qizhou Jiang, Zhehao Ma, Lianmei Tan, , Qi-Jing Li
This study shows that neoadjuvant anti-4-1BB therapy reduces metastasis by enhancing Tint cell clonal expansion and T cell egress in TNBC.
bioRxiv · Jan 29, 2025 · PreprintImmunology