Tao Yin

This study uses a FDD-KI rat model to show that vascular amyloid deposition, neuroinflammation, and white matter damage contribute to motor dysfunction in Familial Danish Dementia.

This study develops and characterizes humanized TNFα inhibitory nanobodies with picomolar potency and low immunogenicity for therapeutic use in TNFα-mediated diseases.

This study shows that neoadjuvant anti-4-1BB therapy reduces metastasis by enhancing Tint cell clonal expansion and T cell egress in TNBC.

The paper shows BRI2 regulates TREM2 processing in microglia, affecting Alzheimer's disease risk, and suggests BRI2 as a therapeutic target.

The paper assesses spatial learning and sequencing task capabilities in knock-in rats with humanizing mutations in the App gene, finding they can learn basic tasks but not more complex ones.

The paper investigates early pathogenic changes in young rats with the Danish mutation in Itm2b, showing altered glutamatergic synaptic function and human Aβ levels.

The paper shows that the p.R47H TREM2 variant reduces GABAergic transmission in young Alzheimer rats, mediated by TNF-α, before Aβ accumulation and brain pathology.