Author

Chengsong Yan

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Xiao‐Fan WangiD· 3 shared Bryan Jian Wei LimiD· 2 shared Christopher C. PaniD· 2 shared Ergang WangiD· 2 shared Kun XiangiD· 2 shared Lianmei TaniD· 2 shared Liuyang WangiD· 2 shared Qi-Jing LiiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Xiao‐Fan WangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-Cell Mendelian Randomization Identifies Cell-Type Specific Genetic Drivers of Lung Cancer Subtypes

Qimao Yang, Chengsong Yan, Xiao‐Fan Wang

This study uses single-cell Mendelian Randomization to identify cell-type specific genetic drivers of lung cancer subtypes, finding 375 causal links and five consistent genes across tissues.

medRxiv · Dec 2, 2025 · PreprintGenetic & Genomic Medicine

Amyloid-β precursor protein promotes tumor growth by establishing an immune-exclusive tumor microenvironment

Tao Yin, Guoping Wang, Zhehao Ma, Liuyang Wang, Rui Chen, Kun Xiang, Lianmei Tan, Yan Wang, Mengyang Chong, Yaosi Liang, Christopher C. Pan, Peter B. Alexander, Bryan Jian Wei Lim, Ergang Wang, Bushangqing Liu, , Xiao‐Fan Wang

This study shows that amyloid-β precursor protein (APP) promotes tumor growth by creating an immune-exclusive tumor microenvironment through suppression of CD8+ T cell and NK cell immunity.

bioRxiv · Feb 10, 2025 · PreprintCancer Biology

Neoadjuvant anti-4-1BB confers protection against spontaneous metastasis through low-affinity intratumor CD8+ T cells in triple-negative breast cancer

Bryan Jian Wei Lim, Mingyong Liu, Liuyang Wang, Sharleen Li Ying Kong, Tao Yin, Chengsong Yan, Kun Xiang, Chengjie Cao, Haiyang Wu, Ariana Mihai, Felicia P. Tay, Ergang Wang, Qizhou Jiang, Zhehao Ma, Lianmei Tan, , Qi-Jing Li

This study shows that neoadjuvant anti-4-1BB therapy reduces metastasis by enhancing Tint cell clonal expansion and T cell egress in TNBC.

bioRxiv · Jan 29, 2025 · PreprintImmunology