Sphingosine-1-phosphate (S1P) signaling as a novel therapeutic target for alcohol abuse.
Irene Lorrai, Riccardo Maccioni, Chenhao Wu, Chase A. Shankula, Jorge Marquez Gaytan, Itzamar Torres, Roberta Puliga, Vez Repunte‐Canonigo, Pietro Paolo Sanna
This study shows that S1P receptor agonists reduce alcohol drinking in rodent models and identify S1P signaling as a potential therapeutic target for alcohol use disorder.
bioRxiv · Nov 15, 2025 · PreprintNeuroscience