Author

Irene Lorrai

Scripps Research InstituteORCID 0000-0003-1452-481XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Itzamar Torres· 3 shared Pietro Paolo SannaiD· 3 shared Riccardo MaccioniiD· 3 shared Roberta PuligaiD· 3 shared Vez Repunte‐CanonigoiD· 3 shared Jorge Marquez Gaytan· 2 shared Chase A. ShankulaiD· 1 shared Chenhao Wu· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 34 mutual co-author links

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3 shared papersNeuroscience

Itzamar Torres

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 16, 2025

N6-methyladenosine RNA methylation is a novel epitranscriptomic regulator of excessive alcohol drinking and vulnerability to relapse

Riccardo Maccioni, Irene Lorrai, Itzamar Torres…·Pietro Paolo Sanna

This study shows that N6-methyladenosine (m6A) RNA methylation regulates alcohol drinking and relapse by altering gene expression in the hippocampus of mice.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 15, 2025

Gene network inference and master regulator analysis identifies the estrogen-related receptor gamma (ERRγ) as a therapeutic target for alcohol use disorder (AUD).

Irene Lorrai, Riccardo Maccioni, Itzamar Torres…·Pietro Paolo Sanna

DOI 10.1101/2025.11.15.688629

humanmouse

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 15, 2025

Sphingosine-1-phosphate (S1P) signaling as a novel therapeutic target for alcohol abuse.

Irene Lorrai, Riccardo Maccioni, Chenhao Wu…·Pietro Paolo Sanna

This study shows that S1P receptor agonists reduce alcohol drinking in rodent models and identify S1P signaling as a potential therapeutic target for alcohol use disorder.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky