Structural and mechanistic insights into inhibition of the type I-F CRISPR-Cas surveillance complex by AcrIF4
Zhengyu Gao, Laixing Zhang, Zihao Ge, Hao Wang, Yourun Yue, Zhuobing Jiang, Xin Wang, Chenying Xu, Yi Zhang, Maojun Yang, Yue Feng
This study investigates how AcrIF4 inhibits the type I-F CRISPR-Cas system by preventing Cas2/3 recruitment, not by blocking DNA binding.
bioRxiv · Aug 30, 2022 · PreprintMolecular Biology