Yue Feng

Balancing of immune activation and suppression during phage infection

The paper shows how phages evade bacterial immune systems by using allelic variation and an anti-defense hotspot, revealing a similarity to a human protein.

Structural insights into type I and type II Lamassu anti-phage systems

The paper presents cryo-EM structures of type I and II Lamassu systems from different bacteria, revealing their architecture and mechanism of DNA cleavage.

CRISPR-Cas supervises diverse anti-phage defense systems

This study shows CRISPR-Cas regulates diverse anti-phage systems via crlRNAs, balancing their expression to prevent autoimmunity and enhance anti-phage defense.

Exploring the diversity of anti-defense systems across prokaryotes, phages, and mobile genetic elements

The paper develops AntiDefenseFinder to detect anti-defense systems in prokaryotes, phages, and MGEs, identifying 47,981 systems and revealing their distribution and evolutionary dynamics.

Phage CRISPR-like regulatory RNAs silence multilayered bacterial immune systems

The paper identifies viral crlRNAs that suppress bacterial immunity by reprogramming Cas proteins and demonstrates their potential for mammalian genome editing.

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

Structural and mechanistic insights into inhibition of the type I-F CRISPR-Cas surveillance complex by AcrIF4

This study investigates how AcrIF4 inhibits the type I-F CRISPR-Cas system by preventing Cas2/3 recruitment, not by blocking DNA binding.

Structural and functional insights into the type III-E CRISPR-Cas immunity

This study reveals the structural and functional mechanisms of the type III-E CRISPR-Cas system by analyzing gRAMP-crRNA complexes and their interactions with target RNA.