Laixing Zhang

Allele-specific splicing modulates protein isoforms and Alzheimer's risk

The paper identifies allele-specific splicing events in brain tissues linked to Alzheimer's disease risk and functional genetic variation.

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

Structural and mechanistic insights into inhibition of the type I-F CRISPR-Cas surveillance complex by AcrIF4

This study investigates how AcrIF4 inhibits the type I-F CRISPR-Cas system by preventing Cas2/3 recruitment, not by blocking DNA binding.

Structural and functional insights into the type III-E CRISPR-Cas immunity

This study reveals the structural and functional mechanisms of the type III-E CRISPR-Cas system by analyzing gRAMP-crRNA complexes and their interactions with target RNA.

Structure of intact human MCU supercomplex with the auxiliary MICU subunits

The paper presents cryo-EM structures of human MCU supercomplexes with and without MICU subunits, showing MICUs do not block the pore but may modulate gating.