Author

Zhengyu Gao

State Key Laboratory of Chemical Resource EngineeringORCID 0000-0002-6777-8840Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Laixing ZhangiD· 3 shared Maojun YangiD· 3 shared Yue FengiD· 3 shared Feixue LiiD· 2 shared Hao WangiD· 2 shared Chenying Xu· 1 shared Hao WangiD· 1 shared Jianwei ZengiD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersMolecular Biology

Laixing ZhangORCID

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3 papers

Recent·Most cited

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

Laixing Zhang, Hao Wang, Jianwei Zeng, Xueli Cao, Zhengyu Gao, Zihe Liu, Feixue Li, Jiawei Wang, Yi Zhang, Maojun Yang, Yue Feng

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

Nature Chemical Biology · Jul 8, 2024Peer-reviewedMicrobiology

Structural and mechanistic insights into inhibition of the type I-F CRISPR-Cas surveillance complex by AcrIF4

Zhengyu Gao, Laixing Zhang, Zihao Ge, Hao Wang, Yourun Yue, Zhuobing Jiang, Xin Wang, Chenying Xu, Yi Zhang, Maojun Yang, Yue Feng

This study investigates how AcrIF4 inhibits the type I-F CRISPR-Cas system by preventing Cas2/3 recruitment, not by blocking DNA binding.

bioRxiv · Aug 30, 2022 · PreprintMolecular Biology

Structural and functional insights into the type III-E CRISPR-Cas immunity

Xi Liu, Laixing Zhang, Hao Wang, Yu Xiu, Ling Huang, Zhengyu Gao, Ningning Li, Feixue Li, Weijia Xiong, Teng Fei Gao, Yi Zhang, Maojun Yang, Yue Feng

This study reveals the structural and functional mechanisms of the type III-E CRISPR-Cas system by analyzing gRAMP-crRNA complexes and their interactions with target RNA.

bioRxiv · Aug 22, 2022 · PreprintMolecular Biology