Distinct age- and pathology-dependent epitranscriptome and translational dysfunction in a tauopathy mouse model
Guangxin Sun, Weiwei Lin, Ruixi Chen, Lulu Jiang, Michael S. DeMott, Abigail E. McShane, Chi Kong Chan, Dylan J. Ehrbar, Xiaoling Zhang, Thomas J. Begley, Andrew Emili, Benjamin L. Wolozin, Peter C. Dedon
This study investigates age- and pathology-dependent changes in the epitranscriptome and translational dysfunction in a tauopathy mouse model, revealing significant alterations in tRNA biology and codon usage patterns.
bioRxiv · May 15, 2025 · PreprintNeuroscience