Author

Guangxin Sun

Massachusetts Institute of TechnologyORCID 0000-0001-6036-8809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Peter C. DedoniD· 4 shared Jingjing SuniD· 3 shared Benjamin L. WoloziniD· 2 shared Lulu JiangiD· 2 shared Sherif RashadiD· 2 shared Thomas J. BegleyiD· 2 shared Abdulrahman MousaiD· 1 shared Abigail E. McShane· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Peter C. DedonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologyOpen BiologyPeer-reviewedApr 15, 2026

tRNA Modification Landscapes in Streptococci: Shared Losses and Clade-Specific Adaptations

Ho‐Ching Tiffany Tsui, Chi‐Kong Chan, Yifeng Yuan…·Valérie de Crécy‐Lagard

This study maps tRNA modifications in Streptococcus mutans and S. pneumoniae, revealing shared losses and clade-specific adaptations in modification genes and metabolic strategies.

4 citationstop 5%

multiple speciesproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 15, 2025

Distinct age- and pathology-dependent epitranscriptome and translational dysfunction in a tauopathy mouse model

Guangxin Sun, Weiwei Lin, Ruixi Chen…·Peter C. Dedon

This study investigates age- and pathology-dependent changes in the epitranscriptome and translational dysfunction in a tauopathy mouse model, revealing significant alterations in tRNA biology and codon usage patterns.

DOI 10.1101/2025.05.15.654371

mouseproteomics

𝕏 PostBluesky

Molecular BiologybioRxivPreprintFeb 14, 2024

Translational response to mitochondrial stresses is orchestrated by tRNA modifications.

Sherif Rashad, Shadi Al-Mesitef, Abdulrahman Mousa…·Kuniyasu Niizuma

The paper shows that tRNA modifications regulate the translational response to mitochondrial stress by altering codon decoding and pathway activity.

16 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 28, 2023

Accumulation of m6A exhibits stronger correlation with MAPT than beta-amyloid pathology in an APP NL-G-F /MAPT P301S mouse model of Alzheimer's disease

Lulu Jiang, Rebecca Roberts, Melissa Wong…·Benjamin L. Wolozin

This study shows that m6A accumulation correlates more strongly with MAPT pathology than beta-amyloid in an Alzheimer's mouse model.

5 citations

mouseexperimental assay

𝕏 PostBluesky