Author

Abigail E. McShane

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Peter C. DedoniD· 2 shared Thomas J. BegleyiD· 2 shared Andrew EmiliiD· 1 shared Benjamin L. WoloziniD· 1 shared Chi Kong Chan· 1 shared Dylan J. EhrbariD· 1 shared Guangxin SuniD· 1 shared Katherine L. CotteniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Peter C. DedonORCID

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2 papers

Recent·Most cited

Loss of the s2U tRNA modification induces antibiotic tolerance and is linked to changes in ribosomal protein expression

Katherine L. Cotten, Abigail E. McShane, Peter C. Dedon, Thomas J. Begley, Kimberly Michele Davis

The paper shows that loss of s2U tRNA modification in Yersinia pseudotuberculosis leads to antibiotic tolerance by reducing ribosomal protein translation.

bioRxiv · Jul 1, 2025 · PreprintMicrobiology

Distinct age- and pathology-dependent epitranscriptome and translational dysfunction in a tauopathy mouse model

Guangxin Sun, Weiwei Lin, Ruixi Chen, Lulu Jiang, Michael S. DeMott, Abigail E. McShane, Chi Kong Chan, Dylan J. Ehrbar, Xiaoling Zhang, Thomas J. Begley, Andrew Emili, Benjamin L. Wolozin, Peter C. Dedon

This study investigates age- and pathology-dependent changes in the epitranscriptome and translational dysfunction in a tauopathy mouse model, revealing significant alterations in tRNA biology and codon usage patterns.

bioRxiv · May 15, 2025 · PreprintNeuroscience