Lulu Jiang

Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy

The paper maps protein interaction network remodeling in a mouse tauopathy model using multi-omics and machine learning, identifying key complexes involved in early disease phenotypes.

Structural and compositional profiling of individual biomolecular assemblies by infrared absorbance-modulated evanescent scattering

This paper introduces IR-AMES, a technique for ultrasensitive structural and compositional analysis of individual biomolecular assemblies in aqueous environments, revealing insights into tau oligomers and their interactions with membranes.

Modeling Alzheimer's Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic Targets

The paper develops a 3D brain assembloid model to study Alzheimer's disease progression and identifies IGFBP pathways as therapeutic targets in APOE4 carriers.

Functional rescue of a fatal ERAD mutation via alternative splicing

This study reports the discovery of using antisense oligonucleotides (ASOs) to rescue the biallelic SEL1L C141Y variant, offering a potential therapeutic strategy.

Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer's disease

This study shows that tau oligomerization causes nuclear membrane invagination and lamina disruption in Alzheimer's disease, linking nuclear stress to neurodegeneration.

Distinct age- and pathology-dependent epitranscriptome and translational dysfunction in a tauopathy mouse model

This study investigates age- and pathology-dependent changes in the epitranscriptome and translational dysfunction in a tauopathy mouse model, revealing significant alterations in tRNA biology and codon usage patterns.

Accumulation of m6A exhibits stronger correlation with MAPT than beta-amyloid pathology in an APP NL-G-F /MAPT P301S mouse model of Alzheimer's disease

This study shows that m6A accumulation correlates more strongly with MAPT pathology than beta-amyloid in an Alzheimer's mouse model.

Single cell transcriptomic profiling of tauopathy in a novel 3D neuron-astrocyte coculture model

The paper develops a 3D neuron-astrocyte coculture model to study tauopathy, showing it recapitulates pathological features and responds to HSP90 inhibitor treatment.

A Complex Containing HNRNPA2B1 and N6-methyladenosine Modified Transcripts Mediates Actions of Toxic Tau Oligomers

This paper identifies a complex involving HNRNPA2B1, N6-methyladenosine modified transcripts, and toxic tau oligomers that mediates neurodegeneration.