Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development
Mei‐Jou Chen, Chia‐Hung Chou, Tsun‐Hsien Hsiao, Tien-Yu Wu, Chi‐Ying Li, Yi‐Lung Chen, Kuang‐Han Chao, Tzong‐Huei Lee, Ronnie Gicaraya Gicana, Chao-Jen Shih, Guo-Jie Brandon-Mong, Yi-Li Lai, Po-Ting Li, Yu-Lin Tseng, Po‐Hsiang Wang, Yin‐Ru Chiang
This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.
Gut Microbes · Nov 7, 2024Peer-reviewedMicrobiology