A Suite of Biochemical and Cell-Based Assays for the Characterization of KRAS Inhibitors and Degraders
Medhanie Kidane, Rene M. Hoffman, Jennifer K. Wolfe-Demarco, Ting-Yu Huang, Chi-Ling Teng, Saheli Samanta, Luis M. Gonzalez Lira, Jennifer Lin‐Jones, Gabriel Pallares, Jane E. Lamerdin, Nicole B. Servant, Chun-Yao Lee, Chao-Tsung Yang, Jean A. Bernatchez
The paper develops biochemical and cell-based assays to evaluate KRAS inhibitors and degraders, generating selectivity profiles and dissociation constants for various KRAS mutants.
ACS Pharmacology & Translational Science · Dec 2, 2024Peer-reviewedPharmacology & Toxicology