Author

Nicole B. Servant

Eurofins (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Gabriel Pallares· 2 shared Jean A. BernatcheziD· 2 shared Jennifer K. Wolfe-Demarco· 2 shared Luis M. Gonzalez Lira· 2 shared Medhanie Kidane· 2 shared Alastair J. King· 1 shared Alexander Michael CliffordiD· 1 shared Andrew M. Hanna· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPharmacology & Toxicology

Gabriel Pallares

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Author profile →

3 papers

Recent·Most cited

SH2scan: Mapping SH2 domain-ligand binding selectivity for inhibitors and degraders

Luis M. Gonzalez Lira, Jennifer K. Wolfe-Demarco, Alexander Michael Clifford, Tuan D. Le, Ghadeer M. Khasawneh, Medhanie Kidane, Michelle Nguyen, Julia A. Najera, Gabriel Pallares, Nicole B. Servant, Jean A. Bernatchez

SH2scan quantifies ligand-SH2 domain interactions across >80% of targets, revealing binding selectivity and KDs to aid in designing selective inhibitors and degraders.

Journal of Medicinal Chemistry · Jan 16, 2026Peer-reviewedPharmacology & Toxicology

Comprehensive Characterization of BTK Inhibitor Specificity, Potency, and Biological Effects: Insights into Covalent and Non-covalent Mechanistic Signatures

Antonia C. Darragh, Andrew M. Hanna, Justin H. Lipner, Alastair J. King, Nicole B. Servant, Mirza Jahic

This paper characterizes the potency, selectivity, and biological effects of fifteen BTK inhibitors, revealing differences between covalent and non-covalent inhibitors in binding affinity and off-target effects.

ACS Pharmacology & Translational Science · Mar 12, 2025Peer-reviewedPharmacology & Toxicology

A Suite of Biochemical and Cell-Based Assays for the Characterization of KRAS Inhibitors and Degraders

Medhanie Kidane, Rene M. Hoffman, Jennifer K. Wolfe-Demarco, Ting-Yu Huang, Chi-Ling Teng, Saheli Samanta, Luis M. Gonzalez Lira, Jennifer Lin‐Jones, Gabriel Pallares, Jane E. Lamerdin, Nicole B. Servant, Chun-Yao Lee, Chao-Tsung Yang, Jean A. Bernatchez

The paper develops biochemical and cell-based assays to evaluate KRAS inhibitors and degraders, generating selectivity profiles and dissociation constants for various KRAS mutants.

ACS Pharmacology & Translational Science · Dec 2, 2024Peer-reviewedPharmacology & Toxicology