Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle
Miki Jishage, Keiichi Ito, Chi-Shuen Chu, Xiaoling Wang, Masashi Yamaji, Robert G. Roeder
This study shows that Gdown1 ablation reduces Pol II recruitment to metabolic genes, leading to cell cycle re-entry and p53-dependent changes in hepatocytes.
Genes & Development · Jun 1, 2020Peer-reviewedMolecular Biology