Robert G. Roeder

The paper shows that BET bromodomain inhibition does not repress estrogen receptor oncogenic targets due to transcriptional coactivator cooperativity.

This study shows that acetylation of MED1's IDR affects PIC assembly, chromatin organization, and gene expression in ER+ breast cancer cells.

This study identifies PAF1 and FACT as essential for enhancer activity in MLL-AF4-driven leukemia by maintaining histone acetylation and enhancer-promoter interactions.

This study shows that DOT1L regulates transcriptional initiation by facilitating TFIID recruitment and modulating H2B monoubiquitination, challenging its previously assumed role in transcriptional elongation.

This study shows that Gdown1 ablation reduces Pol II recruitment to metabolic genes, leading to cell cycle re-entry and p53-dependent changes in hepatocytes.

The paper shows that RNA Polymerase II directly regulates tRNA gene expression by interfering with RNA Polymerase III function, specifically during serum starvation.