Functional Activity of HIV-1 bNAbs Across Diverse Strains is Driven by Binding Site and Can be Enhanced Through Fc Engineering
Chia Jung Li, Eunice Lim, Meredith Phelps, Jacqueline M. Brady, Vintus Okonkwo, Caitlin McCarthy, Caroline Alexander, Margaret E. Ackerman, Daniel Lingwood, Alejandro Benjamin Balazs
This study evaluates how bNAb epitope specificity, Env sequence, and Fc engineering affect antibody-mediated effector functions against diverse HIV-1 strains.
bioRxiv · Nov 12, 2025 · PreprintImmunology