Margaret E. Ackerman

Interaction with complement factor C1q can contribute to and improve monoclonal antibody-mediated protection against lethal HSV-1 challenge

This study shows that modifying monoclonal antibodies to interact with complement factor C1q can enhance or reduce their ability to protect against lethal HSV-1 infection in neonatal mice.

Convergent strategies for nanobody-mediated inhibition of an epoxide hydrolase

The paper identifies two classes of nanobodies that inhibit Cif, an epoxide hydrolase from Pseudomonas aeruginosa, through distinct structural strategies targeting a shared epitope.

RNA-Encoded PGT121-LS Anti-HIV Antibody: Comprehensive Preclinical Characterization and Translational Pharmacokinetics

This paper presents an RNA-encoded bNAb platform for in vivo production of PGT121-LS, showing prolonged half-life and potent neutralization in mice and non-human primates.

Maternal vaccination timing shapes the composition and maturation of antibody clonotypes transferred to the newborn

This study examines how maternal vaccination timing affects antibody clonotype transfer to newborns, finding that earlier vaccination leads to more diverse but less persistent clonotypes, while later vaccination results in more persistent, affinity-matured antibodies in cord blood.

RAD: A Read-structure Agnostic Demultiplexer for Single-Cell Long-Read Sequencing and Analysis

RAD is a demultiplexer for single-cell long-read sequencing that improves speed and sensitivity over existing methods while supporting complex read structures.

Late induction of IgG4 following SARS-CoV-2 mRNA vaccination in pregnant and non-pregnant individuals includes clonotypes raised early in the response

This study examines how pregnancy affects humoral immunity after SARS-CoV-2 mRNA vaccination, finding delayed IgG4 induction and clonotype characteristics associated with pregnancy.

Prefusion-specific glycoprotein B human antibodies protect against neonatal HSV-2 infection

The paper identifies prefusion-specific human antibodies against HSV-2 gB that neutralize both HSV-1 and HSV-2 and protect neonatal mice.

Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice

This study shows that gB-targeting antibodies protect neonatal mice from HSV infection, requiring both neutralization and Fc effector functions, with transgenerational protection achievable via AAV-mediated delivery.

Intranasal Replicating Adenovirus type 4-SARS-CoV-2 Recombinants Induce Superior Immune Response Durability and Efficacy in Preclinical Testing Compared to Standard Intramuscular Vaccines

This study compares intranasal and intramuscular vaccines, finding that the intranasal Ad4-S vaccine provides more durable and effective immune responses against SARS-CoV-2 in preclinical models.

Improving antibody-mediated protection against HSV infection by eliminating interactions with the viral Fc receptor gE/gI

The study shows engineered antibodies lacking Fc receptor binding improve HSV protection, suggesting vaccine strategies targeting IgG3 could enhance immunity.

Functional Activity of HIV-1 bNAbs Across Diverse Strains is Driven by Binding Site and Can be Enhanced Through Fc Engineering

This study evaluates how bNAb epitope specificity, Env sequence, and Fc engineering affect antibody-mediated effector functions against diverse HIV-1 strains.

Effects and mechanisms of monoclonal and polyclonal human antibodies in protection of humanized mice from HIV-1 challenge

This study evaluates how monoclonal and polyclonal human antibodies protect humanized mice from HIV-1 infection, showing that both neutralization and Fc-mediated effects contribute to protection.

Depletion and recovery of IgG following treatment with Rozanoliximab and Imlifidase in pigtail macaques

This study evaluates IgG depletion in pigtail macaques using Rozanoliximab and Imlifidase, finding that Imlifidase causes more rapid and effective depletion than Rozanoliximab.

Cancer therapy via neoepitope-specific monoclonal antibody cocktails

This paper demonstrates the use of neoepitope-specific monoclonal antibody cocktails to treat B16F10 melanoma by targeting unique tumor mutations, showing in vitro and in vivo efficacy.

Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.

This study uses single-cell lineage tracing to show that CD8 T-cell clones exhibit differential fate commitment during acute infection, with some clones adopting memory or effector biases over time.

Humoral correlate of vaccine-mediated protection from tuberculosis identified in humans and non-human primates

The paper identifies a humoral correlate of protection against tuberculosis in humans and non-human primates, showing cross-species and vaccine regimen consistency.

A Comparison of Antibody-Antigen Complex Sequence-to-Structure Prediction Methods and their Systematic Biases

This study compares six methods for predicting antibody-antigen complex structures from sequences, finding that AlphaFold-Multimer performs best but faces limitations due to insufficient interfacial geometry data.

Leveraging Permutation Testing to Assess Confidence in Positive-Unlabeled Learning Applied to High-Dimensional Biological Datasets

This paper introduces a permutation testing approach to evaluate PU learning models using KP samples without ground truth labels, showing its effectiveness on synthetic and real datasets.

IgG is differentially and selectively transferred across the placenta in HIV-infected women

This study identifies factors affecting placental IgG transfer efficiency in HIV-infected women, showing that maternal disease progression and Fc region characteristics influence selective transfer of antigen-specific IgG.