Alejandro Benjamin Balazs

This study shows that gB-targeting antibodies protect neonatal mice from HSV infection, requiring both neutralization and Fc effector functions, with transgenerational protection achievable via AAV-mediated delivery.

This paper uses humanized mice to study how HIV resistance to broadly neutralizing antibodies (bNAbs) affects the efficacy of AAV-delivered immunotherapy, finding that escape mutation fitness costs and resistance benefits determine therapeutic success.

This study evaluates how bNAb epitope specificity, Env sequence, and Fc engineering affect antibody-mediated effector functions against diverse HIV-1 strains.

This study evaluates how monoclonal and polyclonal human antibodies protect humanized mice from HIV-1 infection, showing that both neutralization and Fc-mediated effects contribute to protection.

This study evaluates the effect of combining antiretroviral therapy (ART) with TIGIT or KLRG1 blockade in humanized mice, showing improved HIV-1 suppression and delayed viral rebound.

This study identifies immune signatures associated with SARS-CoV-2 infection resolution in human lung tissues using a humanized mouse model.

Combining dendritic cell stimulation with anti-TIGIT antibodies enhances memory NK cell cytotoxicity against HIV-1 infected CD4+ T cells in vitro and in vivo.

This paper introduces a high-throughput method for screening antibody neutralization using droplet arrays, demonstrating scalable functional antibody data collection against viral diseases.

QuickFit quantifies viral growth and fitness in vitro using high-throughput RT-qPCR, offering higher throughput and lower error than traditional methods.

The paper shows that fetal lung contains hemogenic endothelial cells capable of undergoing endothelial to hematopoietic transition to generate de-novo hematopoietic stem and progenitor cells.

The paper identifies LY6A as a novel receptor for AAV-PHP.B vectors, enabling efficient gene delivery across the blood-brain barrier in mice.