Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates, and humans
Josephine Jüttner, Arnold Szabó, Brigitte Gross Scherf, Rei Morikawa, Santiago B. Rompani, Miguel Teixeira, Péter Hantz, Tamás Szikra, Federico Esposti, Cameron S. Cowan, Arjun Bharioke, Claudia P. Patino-Alvarez, Özkan Keles, Chiara N. Roth, Ákos Kusnyerik, , Botond Roska
The paper develops synthetic promoter AAVs for cell-type-specific gene delivery in mice, non-human primates, and humans, showing 11% of AAVs target neuronal and glial cell types in multiple species.
Nature Neuroscience · Jul 8, 2019Peer-reviewedNeuroscience