Botond Roska

This paper introduces a modular chronic cranial platform for longitudinal multimodal recording in a gyrencephalic brain, validated in cats with functional implants lasting up to 3.3 years.

The paper screens 2,707 compounds in human retinal organoids to identify those that protect or damage cone photoreceptors, finding CK1 and MAPK11 inhibitors as protective.

The paper uses RNA electroporation to knock out GABA-A receptor β subunits in cortical neurons, revealing sequential adaptation mechanisms to excitatory-inhibitory imbalance.

This paper engineers human TRPV1 channels to detect near-infrared light by shifting their temperature sensitivity, enabling light-induced heat activation in retinal cells without immunogenicity issues.

The paper shows that axonal propagation speeds in the human retina adjust to compensate for differences in axon length, ensuring synchronized action potential arrival times at the optic disc.

The paper shows that head direction in mice is driven by both visual and vestibular signals, with visual signals dominating at low speeds and affecting navigational behavior.

This paper develops an implantable biohybrid nerve model for synaptic deep brain stimulation, demonstrating in vitro and in vivo functionality for over 22 days.

The paper identifies functional specialization in thalamic inhibitory interneurons towards distinct visual features using single-cell tracing and in vivo imaging.

The paper improves positively tuned voltage indicators by enhancing their kinetics and contrast for better spike detection.

This paper demonstrates sonogenetic stimulation of the brain with high spatiotemporal resolution for visual restoration in rats and rodents.

This study compares cell-type development and transcriptomes in human retinal organoids and adult retinas, finding convergence in transcriptomes and cell-type-specific disease gene expression.

The paper develops synthetic promoter AAVs for cell-type-specific gene delivery in mice, non-human primates, and humans, showing 11% of AAVs target neuronal and glial cell types in multiple species.

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.