Cameron S. Cowan

The paper screens 2,707 compounds in human retinal organoids to identify those that protect or damage cone photoreceptors, finding CK1 and MAPK11 inhibitors as protective.

The paper improves the FLASH-seq protocol for long-read scRNA-seq on ONT, develops barcoding strategies, and presents a bioinformatics pipeline, while highlighting technical challenges.

The paper shows that axonal propagation speeds in the human retina adjust to compensate for differences in axon length, ensuring synchronized action potential arrival times at the optic disc.

The paper introduces FLASH-Seq, a new single-cell RNA-seq method that improves sensitivity and reduces processing time compared to existing protocols.

This study compares cell-type development and transcriptomes in human retinal organoids and adult retinas, finding convergence in transcriptomes and cell-type-specific disease gene expression.

The paper develops synthetic promoter AAVs for cell-type-specific gene delivery in mice, non-human primates, and humans, showing 11% of AAVs target neuronal and glial cell types in multiple species.