Author

Chih Chuan Shih

Agency for Science, Technology and Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Ai Shan Lee· 2 shared Chiea Chuen KhoriD· 2 shared Ching‐Yu ChengiD· 2 shared John Campbell ChambersiD· 2 shared Jun Xian Liew· 2 shared Khai Pang LeongiD· 2 shared Liuh Ling GohiD· 2 shared Neerja KarnaniiD· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Ai Shan Lee

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3 papers

Recent·Most cited

RAPTOR: A Five-Safes approach to a secure, cloud native and serverless genomics data repository

Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Nicolas Bertin, Maxime Hebrard, Chiea Chuen Khor, Zheng Li, Joanna Hui Juan Tan, Wee Yang Meah, Su Qin Peh, Shi Qi Mok, Kar Seng Sim, Jianjun Liu, Ling Wang, Eleanor Wong, , Rajkumar Dorajoo

RAPTOR provides a secure, cloud-native genomics repository with a five-safes framework to ensure compliance and data protection for genomic research.

bioRxiv · Oct 27, 2022 · PreprintGenomics

Detection of genomic alterations in breast cancer with circulating tumour DNA sequencing

Dimitrios Kleftogiannis, Danliang Ho, Jun Xian Liew, Polly S. Y. Poon, Anna Gan, Raymond Chee-Hui Ng, Benita Kiat Tee Tan, Kiang Hiong Tay, Swee Ho Lim, Gek San Tan, Chih Chuan Shih, Tony Kiat Hon Lim, Ann S. G. Lee, Iain Beehuat Tan, Yoon Sim Yap, Sarah Boon Hsi Ng

This paper develops a targeted cfDNA sequencing approach for detecting genomic alterations in breast cancer using UMIs and bioinformatics pipelines, showing high concordance with tumor sequencing.

Scientific Reports · Oct 8, 2020Peer-reviewedGenomics

Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

Degang Wu, Jinzhuang Dou, Xiaoran Chai, Claire Bellis, Andreas Wilm, Chih Chuan Shih, Wendy WeiJia Soon, Nicolas Bertin, Clarabelle Bitong Lin, Chiea Chuen Khor, Michael DeGiorgio, Shanshan Cheng, Li Bao, Neerja Karnani, William Ying Khee Hwang, , Yee Yen Sia

This study presents whole-genome sequencing data from 4,810 Singaporeans across three ethnic groups, revealing genetic structure, admixture, and improved imputation for Asian and Oceanian populations.

Cell · Oct 1, 2019Peer-reviewedGenetics