Rajkumar Dorajoo

The paper shows copper and iron regulate cellular survival through distinct TORC1 and AMPK pathways in yeast under nutrient stress.

The paper investigates the relationship between fatty acid metabolism and cellular longevity by integrating interactome analyses, transcriptomics, and lifespan assays in human and yeast.

The paper identifies metabolic state transitions regulated by TORC1 that influence cellular aging in yeast and human cells.

This paper develops and benchmarks BrainAge models using multi-modal neuroimaging data from childhood cohorts to distinguish healthy from symptomatic developmental trajectories.

This study shows mitochondrial competence determines cellular responses to metabolic interventions during aging, with TORC1 signaling and mitochondrial function being key factors.

This study shows that telomerase reverse transcriptase (Tert) is essential for resistance to mycobacterial infection by supporting demand-driven hematopoiesis in zebrafish.

This study uses RNA-sequencing to analyze how calorie restriction and rapamycin affect gene expression in yeast, revealing their synergistic effect in extending postmitotic cell lifespan.

This paper evaluates differences in a breast cancer polygenic risk score across genomic platforms and finds that calibration improves consistency in high-risk classification.

This paper evaluates polygenic risk scores for predicting common cancers in East Asians using a large cohort, finding significant risk stratification for breast, prostate, and colorectal cancers.

RAPTOR provides a secure, cloud-native genomics repository with a five-safes framework to ensure compliance and data protection for genomic research.

This study identifies 12,111 SNPs associated with height from 5.4 million individuals, explaining most common SNP-based heritability and showing ancestry-specific prediction accuracy.

This study presents whole-genome sequencing data from 4,810 Singaporeans across three ethnic groups, revealing genetic structure, admixture, and improved imputation for Asian and Oceanian populations.

The paper analyzes genetic and environmental factors in Israeli kibbutzim to identify cardiometabolic trait associations and population structure.