Author

Chih-chieh Yu

Princeton University

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Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Cai Zhou· 1 shared Cameron MyhrvoldiD· 1 shared Kaiyi JiangiD· 1 shared Long NguyeniD· 1 shared Tommi S Jaakkola· 1 shared Xinyun JiangiD· 1 shared Zijie CheniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

Cai Zhou

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1 paper

Recent·Most cited

Protein Deimmunization with a Generative Diffusion Model

Zijie Chen, Chih-chieh Yu, Cai Zhou, Xinyun Jiang, Long Nguyen, Cameron Myhrvold, Tommi S Jaakkola, Kaiyi Jiang

The paper introduces MESSI, a generative diffusion model for deimmunizing proteins by designing sequences with minimal immunogenicity while preserving structure and function.

bioRxiv · Oct 16, 2026 · PreprintBioengineering