Kaiyi Jiang

Protein Deimmunization with a Generative Diffusion Model

The paper introduces MESSI, a generative diffusion model for deimmunizing proteins by designing sequences with minimal immunogenicity while preserving structure and function.

Engineering synthetic phosphorylation signaling networks in human cells

This paper engineers synthetic phosphorylation signaling networks in human cells to enable dynamic sensing and suppression of activated T cells.

Rapid protein evolution by few-shot learning with a protein language model

This paper introduces EVOLVEpro, a few-shot learning framework using protein language models to rapidly improve protein activity with minimal experimental data.

Programmable RNA-guided endonucleases are widespread in eukaryotes and their viruses

The paper identifies widespread RNA-guided nucleases in eukaryotes and their viruses, showing they can be used for genome editing in human cells.

Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles

The paper reanalyzes millions of molecular profiles to identify aging interventions using AI agents, finding over 500 interventions that reduce biological age and revealing patterns in aging modulation.

RNA-triggered protein cleavage and cell death by the RNA-guided type III-E CRISPR-Cas nuclease-protease complex

This study characterizes the RNA-guided nuclease-protease complex Cas7-11-Csx29, showing target RNA binding activates Csx29 to cleave Csx30, leading to cell death.

Programmable eukaryotic protein expression with RNA sensors

This paper introduces RADARS, a programmable RNA-sensing technology that uses ADAR-mediated RNA editing to control protein expression based on target RNA transcripts in mammalian cells, with applications in gene therapy and synthetic biology.