JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell-derived neural progenitors and cortical neurons.
Reinhard Roessler, Johanna E. Goldmann, Chikdu Shivalila, Rudolf Jaenisch
The paper investigates the role of JIP2 haploinsufficiency in neurodevelopmental abnormalities using human pluripotent stem cells and finds that it impairs neuronal maturation through JNK misregulation and compromised semaphorin signaling.
Life Science Alliance · Jun 25, 2018Peer-reviewedNeuroscience