Author

Chileleko Siachisumo

Newcastle University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Caroline DalglieshiD· 2 shared David J. ElliottiD· 2 shared Gerald Hysenaj· 2 shared Graham R. SmithiD· 2 shared Ingrid E. Ehrmann· 2 shared Jennifer MunkleyiD· 2 shared Katherine JamesiD· 2 shared Kathleen CheungiD· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Caroline DalglieshORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression

Chileleko Siachisumo, Sara Luzzi, Saad Aldalaqan, Gerald Hysenaj, Caroline Dalgliesh, Kathleen Cheung, Matthew R. Gazzara, Ivaylo D Yonchev, Katherine James, Mahsa Kheirollahi Chadegani, Ingrid E. Ehrmann, Graham R. Smith, Simon Cockell, Jennifer Munkley, Stuart A. Wilson, , David J. Elliott

This study shows RBMX and RBMXL2 proteins regulate splicing of ultra-long exons by repressing cryptic splice sites, with RBMXL2 rescuing splicing defects in somatic cells.

eLife · Sep 9, 2024Peer-reviewedMolecular Biology

RBMX enables productive RNA processing of ultra-long exons important for genome stability

Sara Luzzi, Gerald Hysenaj, Chileleko Siachisumo, Kathleen Cheung, Matthew R. Gazzara, Katherine James, Caroline Dalgliesh, Mahsa Kheirollahi Chadegani, Ingrid E. Ehrmann, Graham R. Smith, Simon Cockell, Jennifer Munkley, Yoseph Barash, David J. Elliott

The paper shows RBMX prevents non-productive splicing of ultra-long exons, maintaining genome stability by blocking aberrant splice sites in genes like ETAA1.

bioRxiv · Oct 9, 2020 · PreprintMolecular Biology