Author

Caroline Dalgliesh

Newcastle UniversityORCID 0009-0004-1683-5376Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

David J. ElliottiD· 3 shared Gerald Hysenaj· 3 shared Ingrid E. Ehrmann· 3 shared Jennifer MunkleyiD· 3 shared Kathleen CheungiD· 3 shared Simon CockelliD· 3 shared Chileleko Siachisumo· 2 shared Graham R. SmithiD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

David J. ElliottORCID

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Author profile →

3 papers

Recent·Most cited

An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression

Chileleko Siachisumo, Sara Luzzi, Saad Aldalaqan, Gerald Hysenaj, Caroline Dalgliesh, Kathleen Cheung, Matthew R. Gazzara, Ivaylo D Yonchev, Katherine James, Mahsa Kheirollahi Chadegani, Ingrid E. Ehrmann, Graham R. Smith, Simon Cockell, Jennifer Munkley, Stuart A. Wilson, , David J. Elliott

This study shows RBMX and RBMXL2 proteins regulate splicing of ultra-long exons by repressing cryptic splice sites, with RBMXL2 rescuing splicing defects in somatic cells.

eLife · Sep 9, 2024Peer-reviewedMolecular Biology

RBMX enables productive RNA processing of ultra-long exons important for genome stability

Sara Luzzi, Gerald Hysenaj, Chileleko Siachisumo, Kathleen Cheung, Matthew R. Gazzara, Katherine James, Caroline Dalgliesh, Mahsa Kheirollahi Chadegani, Ingrid E. Ehrmann, Graham R. Smith, Simon Cockell, Jennifer Munkley, Yoseph Barash, David J. Elliott

The paper shows RBMX prevents non-productive splicing of ultra-long exons, maintaining genome stability by blocking aberrant splice sites in genes like ETAA1.

bioRxiv · Oct 9, 2020 · PreprintMolecular Biology

Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

Jennifer Munkley, Ling Li, S R Gokul Krishnan, Gerald Hysenaj, Emma Scott, Caroline Dalgliesh, Htoo Zarni Oo, Teresa Mendes Maia, Kathleen Cheung, Ingrid E. Ehrmann, Karen E. Livermore, Hanna Zielinska, Oliver Thompson, Bridget Knight, Paul J. McCullagh, , David J. Elliott

The paper shows androgen-regulated ESRP2 transcription controls alternative splicing in prostate cancer, with implications for metastasis.

eLife · Sep 3, 2019Peer-reviewedMolecular Biology