MCU-enriched dendritic mitochondria regulate plasticity in distinct hippocampal circuits
Katy E. Pannoni, Quentin S. Fischer, Renesa Tarannum, Mikel L. Cawley, Mayd M. Alsalman, Nicole Acosta, Chisom Ezigbo, Daniela V. Gil, Logan A. Campbell, Shannon Farris
This study shows that MCU regulates synaptic plasticity specifically at CA2 distal dendrites by maintaining mitochondrial morphology and distribution, with loss of MCU causing LTP deficits and mitochondrial fragmentation.
Scientific Reports · Feb 6, 2025Peer-reviewedNeuroscience