Author

Mikel L. Cawley

Virginia TechORCID 0000-0002-0229-3471Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1 Organism:non-human primate· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Shannon FarrisiD· 3 shared Daniela V. GiliD· 2 shared Katy E. PannoniiD· 2 shared Logan A. CampbelliD· 2 shared Mayd M. AlsalmaniD· 2 shared Chisom Ezigbo· 1 shared Derek Wei· 1 shared Gabriela L. Carrillo· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Shannon FarrisORCID

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Author profile →

4 papers

Recent·Most cited

Elevating levels of neuronal MCU in the hippocampus enhances mitochondrial calcium uptake and respiratory efficiency proportional to demand

Mikel L. Cawley, Ryan N. Montalvo, Mason Wheeler, Lucy L. Turner, Jessica M. Pfleger, Zhen Yan, Shannon Farris

This study shows that increasing neuronal MCU in the hippocampus improves mitochondrial calcium uptake and respiratory efficiency in response to energy demand.

bioRxiv · Apr 16, 2026 · PreprintNeuroscience

MCU-enriched dendritic mitochondria regulate plasticity in distinct hippocampal circuits

Katy E. Pannoni, Quentin S. Fischer, Renesa Tarannum, Mikel L. Cawley, Mayd M. Alsalman, Nicole Acosta, Chisom Ezigbo, Daniela V. Gil, Logan A. Campbell, Shannon Farris

This study shows that MCU regulates synaptic plasticity specifically at CA2 distal dendrites by maintaining mitochondrial morphology and distribution, with loss of MCU causing LTP deficits and mitochondrial fragmentation.

Scientific Reports · Feb 6, 2025Peer-reviewedNeuroscience

Layer-specific mitochondrial diversity across hippocampal CA2 dendrites

Katy E. Pannoni, Daniela V. Gil, Mikel L. Cawley, Mayd M. Alsalman, Logan A. Campbell, Shannon Farris

The paper shows that mitochondria in CA2 distal dendrites are larger and enriched in MCU, linking synaptic activity to mitochondrial morphology and function.

Hippocampus · Feb 10, 2023Peer-reviewedNeuroscience

Complement-dependent loss of inhibitory synapses on pyramidal neurons following Toxoplasma gondii infection

Gabriela L. Carrillo, Jianmin Su, Mikel L. Cawley, Derek Wei, Simran K. Gill, Ira J. Blader, Michael A. Fox

This study shows that Toxoplasma gondii infection causes complement-dependent loss of inhibitory synapses on excitatory pyramidal neurons in the neocortex.

Journal of Neurochemistry · Jan 23, 2023Peer-reviewedNeuroscience