Discovery of iridoid cyclase completes the iridoid pathway in asterids
Maite Colinas, Chloée Tymen, Joshua C. Wood, Anja David, Jens Wurlitzer, Clara Morweiser, Klaus Gase, Ryan M. Alam, Gabriel R. Titchiner, John P. Hamilton, Sarah Heinicke, Ron P. Dirks, Adriana A. Lopes, Lorenzo Caputi, C. Robin Buell, Sarah Ellen O'Connor
The paper identifies an enzyme, ICYC, that catalyzes the cyclization of an enol intermediate in the iridoid biosynthesis pathway in asterids, completing the pathway and enabling metabolic engineering of iridoid compounds.
Nature Plants · Oct 3, 2025Peer-reviewedPlant Biology