Jens Wurlitzer

Single-cell metabolome and RNA-seq multiplexing on single plant cells

The paper demonstrates multiplexing single-cell RNA-seq and metabolomics on the same plant cell to directly correlate gene expression and metabolite levels.

Discovery of iridoid cyclase completes the iridoid pathway in asterids

The paper identifies an enzyme, ICYC, that catalyzes the cyclization of an enol intermediate in the iridoid biosynthesis pathway in asterids, completing the pathway and enabling metabolic engineering of iridoid compounds.

Independent evolution of ipecac alkaloid biosynthesis

This study shows that ipecac alkaloid biosynthesis evolved independently in two plant species using different monoterpene precursors and non-enzymatic reactions.

Single-cell mass spectrometry reveals heterogeneous triterpenic acid accumulation in apple callus-derived cells

This study uses single-cell mass spectrometry to reveal metabolic heterogeneity in apple callus cells and shows that abiotic stress increases triterpenic acid production.

BAHD news from Euphorbia peplus: identification of acyltransferase enzymes involved in ingenane diterpenoid biosynthesis

This paper identifies acyltransferase genes involved in ingenol-3-angelate biosynthesis in Euphorbia peplus and shows functional redundancy in acetylation steps.

Quantitative single cell mass spectrometry reveals the dynamics of plant natural product biosynthesis

The paper develops a method for single cell mass spectrometry to quantify natural products in plant cells, revealing biosynthetic dynamics not captured by scRNA-seq.