Klaus Gase

The paper identifies an auxiliary protein, FoGS, that enhances the activity of geissoschizine synthase in producing alkaloid intermediates and controls product stereochemistry.

The paper identifies an enzyme, ICYC, that catalyzes the cyclization of an enol intermediate in the iridoid biosynthesis pathway in asterids, completing the pathway and enabling metabolic engineering of iridoid compounds.

The paper investigates how three cytochrome P450 enzymes in Catharanthus roseus transform 19E-geissoschizine into four distinct alkaloid scaffolds through oxidative transformations.

This study identifies a genetic locus associated with fungal pathogen resistance in wild tobacco plants, showing frequency- and spatially-dependent effects in mixed populations.

This study sequenced wild tobacco genomes to uncover how nicotine biosynthesis evolved through gene duplications and transposable elements.