Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve (BAV) caused by loss of primary cilia
Ahlam Alqahtani, Lorraine Eley, Jake Newton, Kimberley A. Macdonald, Chloe Connolly, Cindy Rodrigues-Cleto, Kristýna Neffeová, Leonor Lopez, Javier Arias, Christopher J. Derrick, Mashael Alaradi, Hana Kolesová, Bill Chaudhry, Deborah J. Henderson
This study shows that loss of primary cilia in second heart field cells causes bicuspid aortic valve by disrupting Notch-Jag1 signaling and altering valve leaflet formation.
Cardiovascular Research · Jun 10, 2025Peer-reviewedDevelopmental Biology