Developmental BiologybioRxivPreprint
Developmental outflow tract abnormalities of Jag1-deficient mice are associated with abnormal ventricular activation and desynchronized contraction.
Kristýna Neffeová, Eva Nekvindová, Veronika Olejníčková, Hana Kolesová
This study shows that Jag1 deficiency in mice causes heart malformations and electrical dysfunction, leading to Tetralogy of Fallot-like defects and mechanical dyssynchrony.