Dominant α-tubulin mutations rescue tauopathy neurodegenerative phenotypes in C. elegans
Sarah J. Benbow, Aleen D. Saxton, Misa Baum, Rikki L. Uhrich, Jade G. Stair, Kelly Keene, Chloe Dahleen, Linda G. Wordeman, Nicole F. Liachko, Rebecca L. Kow, Brian C. Kraemer
This study identifies tubulin gene mutations that rescue tauopathy phenotypes in C. elegans by altering microtubule properties rather than directly affecting tau protein levels or aggregation.
bioRxiv · Mar 20, 2026 · PreprintNeuroscience