Author

Aleen D. Saxton

VA Puget Sound Health Care SystemORCID 0000-0002-5055-5755Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Brian C. KraemeriD· 2 shared Nicole F. LiachkoiD· 2 shared Rebecca L. KowiD· 2 shared Chloe Dahleen· 1 shared Jade G. StairiD· 1 shared Kelly Keene· 1 shared Linda G. WordemaniD· 1 shared Misa Baum· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Brian C. KraemerORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 20, 2026

Dominant α-tubulin mutations rescue tauopathy neurodegenerative phenotypes in C. elegans

Sarah J. Benbow, Aleen D. Saxton, Misa Baum…·Brian C. Kraemer

This study identifies tubulin gene mutations that rescue tauopathy phenotypes in C. elegans by altering microtubule properties rather than directly affecting tau protein levels or aggregation.

DOI 10.64898/2026.03.18.712642

C. elegansexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 11, 2024

TMEM106B C-terminal fragments aggregate and drive neurodegenerative proteinopathy.

Ruben Riordan, Aleen D. Saxton, Pamela J. McMillan…·Brian C. Kraemer

This study identifies TMEM106B C-terminal fragments as aggregating proteins linked to neurodegenerative diseases and shows their toxic effects in a C. elegans model.

2 citations

C. elegansprotein structure

𝕏 PostBluesky