Characterization of Microbubble Cavitation in Theranostic Ultrasound-mediated Blood-Brain Barrier Opening and Gene Delivery
Fotios N. Tsitsos, Alec J. Batts, Daniella Amanda Jimenez, Craig A. Macsemchuk, Chunqi Li, Robin Ji, Sua Bae, Gillian L. Ciaccio, Angeliki Theodorou, Rashell K. Ramirez, Samantha L. Gorman, Chloe L Lugg, Elisa E. Konofagou
This study characterizes microbubble cavitation in theranostic ultrasound-mediated BBB opening and gene delivery, finding that longer pulses and specific microbubble sizes enhance cavitation and transgene expression.
Journal of Controlled Release · Jan 22, 2025Peer-reviewedBioengineering