Elisa E. Konofagou

Transcranial Functional Ultrasound Imaging Detects Focused Ultrasound Neuromodulation Induced Hemodynamic Changes In Vivo

This study uses transcranial functional ultrasound imaging to detect hemodynamic changes induced by focused ultrasound neuromodulation in mice.

A Fully Endovascular Neural Interface

This paper introduces a fully endovascular neural interface that delivers electrical stimulation and recording through a microcatheter, demonstrating blood pressure modulation in rabbits.

Safe focused ultrasound-mediated blood-brain barrier opening is driven primarily by transient reorganization of tight junctions

This study investigates how focused ultrasound opens the blood-brain barrier at low and high pressures, finding that low pressures cause transient tight junction reorganization while high pressures lead to irreversible damage.

Alteration of Water Exchange Rates Following Focused Ultrasound-Mediated BBB Opening in the Dorsal Striatum of Non-Human Primates: A Diffusion-Prepared pCASL Study

This study uses DP-pCASL to measure BBB water exchange rates before and after FUS-mediated BBB opening in non-human primates, finding localized decreases and global increases in Kw.

Transcranial Focused Ultrasound of the Human Subgenual Anterior Cingulate Reconfigures Resting State Connectivity: A Sham-Controlled fMRI Study

This study uses tFUS to modulate sgACC connectivity in healthy adults, showing increased whole-brain connectivity post-treatment and distinct network changes compared to sham.

Mechanical Artifacts During Transcranial Focused Ultrasound Mimic Biologically Evoked Responses

The paper identifies mechanical artifacts in tFUS-induced LFP signals in anesthetized rats, showing they mimic genuine neural responses and are artifact-driven.

Low hemoglobin causes hematoma expansion and poor intracerebral hemorrhage outcomes

This study shows lower hemoglobin levels increase hematoma expansion and poor outcomes in intracerebral hemorrhage using human data and a mouse model.

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson's disease: from rodent models to non-human primates

Portable therapeutic ultrasound enhanced AAV9 delivery to the brain in mice and rhesus macaques compared to systemic injection alone.

Characterization of Microbubble Cavitation in Theranostic Ultrasound-mediated Blood-Brain Barrier Opening and Gene Delivery

This study characterizes microbubble cavitation in theranostic ultrasound-mediated BBB opening and gene delivery, finding that longer pulses and specific microbubble sizes enhance cavitation and transgene expression.

Response of Serum-isolated Extracellular Vesicles to Focused Ultrasound Blood-Brain Barrier Opening

This study examines how FUS-BBBO affects EV concentration and content in mice and AD patients, showing increased EV levels and enhanced biomarker detection.

Automated Tumor and FUS Lesion Quantification on Multi-frequency Harmonic Motion and B-mode Imaging Using a Multi-modality Neural Network

This paper develops HMINet, a transformer-based neural network for automated tumor and FUS lesion quantification using multi-frequency HMI and B-mode imaging, achieving high segmentation accuracy across multiple datasets.

Focused ultrasound enhanced antibody delivery for the treatment of Parkinson's Disease

This study evaluates the feasibility of using focused ultrasound to deliver an anti-alpha-synuclein antibody to Parkinson's disease mouse models, showing successful BBB opening and antibody delivery.

Functional ultrasound (fUS) imaging of displacement-guided focused ultrasound (FUS) neuromodulation in mice

This study uses functional ultrasound imaging to monitor brain tissue displacement and hemodynamic responses during focused ultrasound neuromodulation in mice, showing a correlation between displacement and cerebral blood volume changes.

Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure

This study compares the effects of focused ultrasound alone versus with microbubbles on functional connectivity in non-human primate brains.

Long Term Study of Motivational and Cognitive Effects of Low-intensity Focused Ultrasound Neuromodulation in the Dorsal Striatum of Nonhuman Primates

Neuronal responses to focused ultrasound are gated by pre-stimulation brain rhythms

This study shows that amplitude-modulated tFUS reduces neuronal firing rate, while continuous-wave tFUS increases it, with effects influenced by baseline brain rhythms.

Differential effects of amplitude-modulated transcranial focused ultrasound on excitatory and inhibitory neurons

This study shows that amplitude-modulated transcranial focused ultrasound (AM-tFUS) differentially affects excitatory and inhibitory neurons in the rat hippocampus based on intensity.

Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy

The paper uses MRI and TBM to show that tau pathology spread in a mouse model correlates with brain volume loss but not neuronal loss in specific regions.

Focused ultrasound enhances sensorimotor decision-making in monkeys

This study shows that focused ultrasound improves visual-motor decision-making in monkeys and interacts with haloperidol, suggesting a role for the dorsal striatum in decision-making.