Daniella Amanda Jimenez

This study investigates how focused ultrasound opens the blood-brain barrier at low and high pressures, finding that low pressures cause transient tight junction reorganization while high pressures lead to irreversible damage.

Portable therapeutic ultrasound enhanced AAV9 delivery to the brain in mice and rhesus macaques compared to systemic injection alone.

This study characterizes microbubble cavitation in theranostic ultrasound-mediated BBB opening and gene delivery, finding that longer pulses and specific microbubble sizes enhance cavitation and transgene expression.