Author

Alec J. Batts

Columbia UniversityORCID 0000-0002-6979-9389Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Elisa E. KonofagouiD· 4 shared Fotios N. TsitsosiD· 3 shared Sua BaeiD· 3 shared Daniella Amanda JimeneziD· 2 shared Melody R. DiBenedetto· 2 shared Nancy KwoniD· 2 shared Robin JiiD· 2 shared Samantha L. GormaniD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

Elisa E. KonofagouORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson's disease: from rodent models to non-human primates

Alec J. Batts, Robin Ji, Sua Bae, Fotios N. Tsitsos, Sergio Jiménez-Gambín, Nancy Kwon, Samantha L. Gorman, Deny Tsakri, Rebecca Lynn Noel, Jonas Bendig, Daniella Amanda Jimenez, Melody R. DiBenedetto, Sofia A. Del Castillo, Filimon B. Keleta, James Caicedo, , Elisa E. Konofagou

Portable therapeutic ultrasound enhanced AAV9 delivery to the brain in mice and rhesus macaques compared to systemic injection alone.

bioRxiv · Mar 2, 2025 · PreprintBioengineering

Characterization of Microbubble Cavitation in Theranostic Ultrasound-mediated Blood-Brain Barrier Opening and Gene Delivery

Fotios N. Tsitsos, Alec J. Batts, Daniella Amanda Jimenez, Craig A. Macsemchuk, Chunqi Li, Robin Ji, Sua Bae, Gillian L. Ciaccio, Angeliki Theodorou, Rashell K. Ramirez, Samantha L. Gorman, Chloe L Lugg, Elisa E. Konofagou

This study characterizes microbubble cavitation in theranostic ultrasound-mediated BBB opening and gene delivery, finding that longer pulses and specific microbubble sizes enhance cavitation and transgene expression.

Journal of Controlled Release · Jan 22, 2025Peer-reviewedBioengineering

Response of Serum-isolated Extracellular Vesicles to Focused Ultrasound Blood-Brain Barrier Opening

Alina R. Kline-Schoder, Fotios N. Tsitsos, Alec J. Batts, Melody R. DiBenedetto, Keyu Liu, Sua Bae, Elisa E. Konofagou

This study examines how FUS-BBBO affects EV concentration and content in mice and AD patients, showing increased EV levels and enhanced biomarker detection.

Ultrasound in Medicine & Biology · Dec 20, 2024Peer-reviewedBioengineering

Focused ultrasound enhanced antibody delivery for the treatment of Parkinson's Disease

Nancy Kwon, Alec J. Batts, Hairong Zhang, Vernice R. Jackson-Lewis, Elisa E. Konofagou, Serge Przedborski

This study evaluates the feasibility of using focused ultrasound to deliver an anti-alpha-synuclein antibody to Parkinson's disease mouse models, showing successful BBB opening and antibody delivery.

bioRxiv · Sep 13, 2024 · PreprintNeuroscience