Premorbid Characteristics of the SAPAP3-Mouse Model of Obsessive-Compulsive Disorder: Behavior, Neuroplasticity, and Psilocybin Treatment
Michal Lazar, Michal Brownstien, Alexander Botvinnik, Chloe Shevakh, Orr Shahar, Tzuri Lifschytz, Bernard Lerer
This study examines anxiety-like behaviors and synaptic plasticity in juvenile SAPAP3-KO mice before OCD-like grooming emerges, finding no psilocybin treatment effect and age-dependent synaptic changes.
The International Journal of Neuropsychopharmacology · Mar 29, 2025Peer-reviewedNeuroscience