Alexander Botvinnik

Preclinical Comparison of DMT and 5-MeO-DMT Reveals Behavioral Dissociation, Distinct TrkB Activation and Differential Plasticity Profiles

This study compares the acute pharmacology and long-term neuroplastic effects of DMT and 5-MeO-DMT in mice, showing distinct behavioral and molecular outcomes.

MDMA-Enhanced Exposure Therapy Reverses PTSD-Like Features In a Learned Helplessness Mouse Model

This study shows that MDMA combined with exposure therapy rapidly reduces PTSD-like behaviors in a mouse model, supporting its potential for more efficient PTSD treatment.

Synergistic Behavioral and Neuroplastic Effects of Psilocybin-NMDAR Modulator Administration.

This study combines psilocybin with NMDAR modulators to enhance therapeutic effects and reduce adverse effects in mice, showing improved neuroplasticity and reduced hallucinogenic and antipsychotic-like behaviors.

Premorbid Characteristics of the SAPAP3-Mouse Model of Obsessive-Compulsive Disorder: Behavior, Neuroplasticity, and Psilocybin Treatment

This study examines anxiety-like behaviors and synaptic plasticity in juvenile SAPAP3-KO mice before OCD-like grooming emerges, finding no psilocybin treatment effect and age-dependent synaptic changes.

Striking Long Term Beneficial Effects of Single Dose Psilocybin and Psychedelic Mushroom Extract in the SAPAP3 Rodent Model of OCD-Like Excessive Self-Grooming

This study shows that a single dose of psilocybin or psychedelic mushroom extract reduces excessive self-grooming in SAPAP3 KO mice, with effects lasting up to 7 weeks.

Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 receptors in the head twitch response induced by 5-hydroxytryptophan and psilocybin: Translational implications.

This study investigates the role of 5-HT2A, 5-HT2C, 5-HT1A, and TAAR1 receptors in modulating head twitch response induced by 5-HTP and psilocybin in mice, showing their potential therapeutic relevance.