Author

Orr Shahar

Hebrew University of Jerusalem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander BotvinnikiD· 4 shared Bernard LereriD· 4 shared Tzuri Lifschytz· 4 shared Masha Chaykin· 2 shared May Ben Ari· 2 shared Michal Brownstien· 2 shared Peretz Golding· 2 shared Amit LotaniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersNeuroscience

Alexander BotvinnikORCID

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4 papers

Recent·Most cited

Preclinical Comparison of DMT and 5-MeO-DMT Reveals Behavioral Dissociation, Distinct TrkB Activation and Differential Plasticity Profiles

Orr Shahar, Alexander Botvinnik, Masha Chaykin, Amit Shwartz, Elad Lerer, Peretz Golding, May Ben Ari, Ori Shalev, Tzuri Lifschytz, Bernard Lerer

This study compares the acute pharmacology and long-term neuroplastic effects of DMT and 5-MeO-DMT in mice, showing distinct behavioral and molecular outcomes.

bioRxiv · Aug 12, 2026 · PreprintNeuroscience

MDMA-Enhanced Exposure Therapy Reverses PTSD-Like Features In a Learned Helplessness Mouse Model

Orr Shahar, Peretz Golding, Masha Chaykin, May Ben Ari, Alexander Botvinnik, Tzuri Lifschytz, Bernard Lerer

This study shows that MDMA combined with exposure therapy rapidly reduces PTSD-like behaviors in a mouse model, supporting its potential for more efficient PTSD treatment.

bioRxiv · Aug 12, 2026 · PreprintNeuroscience

Premorbid Characteristics of the SAPAP3-Mouse Model of Obsessive-Compulsive Disorder: Behavior, Neuroplasticity, and Psilocybin Treatment

Michal Lazar, Michal Brownstien, Alexander Botvinnik, Chloe Shevakh, Orr Shahar, Tzuri Lifschytz, Bernard Lerer

This study examines anxiety-like behaviors and synaptic plasticity in juvenile SAPAP3-KO mice before OCD-like grooming emerges, finding no psilocybin treatment effect and age-dependent synaptic changes.

The International Journal of Neuropsychopharmacology · Mar 29, 2025Peer-reviewedNeuroscience

Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 receptors in the head twitch response induced by 5-hydroxytryptophan and psilocybin: Translational implications.

Orr Shahar, Alexander Botvinnik, Noam Esh-Zuntz, Michal Brownstien, Rachel Wolf, Amit Lotan, Gilly Wolf, Bernard Lerer, Tzuri Lifschytz

This study investigates the role of 5-HT2A, 5-HT2C, 5-HT1A, and TAAR1 receptors in modulating head twitch response induced by 5-HTP and psilocybin in mice, showing their potential therapeutic relevance.

International Journal of Molecular Sciences · Nov 16, 2022Peer-reviewedNeuroscience